[SGranjeaud]

Here is the answer of Antonio Cosma to the initial message of Berndt

Dear Bernd,

I think is really an interesting question.

I fully agree about the arcsinh transformation with cofactor adjustment.

Some time ago, I created a dashboard to show how arcsinh transformation may affect clustering and z-score: https://public.tableau.com/app/profile/a...clustering

I always wondered whether moving a cytometry dataset far from 0 could improve the analysis in some way. We should also separate flow from mass cytometry data since their relation with the space close to zero is quite different.

Happy to discuss the subject
Best
Antonio